The constant advances in sciences and technologies encourage industrialist and researchers in manufacturing, to address new challenges relevant to industrial Cyber-Physical Systems (CPS). Human aspects, among others, are of importance and researchers try to take them into account, but they remain to be efficiently dealt with during the design of industrial CPS. The goal of this paper is to highlight how it is possible to integrate “human-in-the-loop” inside the process control of industrial CPS. For that purpose, studies coming from the domain of industrial engineering are presented in the next part. It is completed by an overview of the main cognitive dimensions industrial designers have to integrate in assistance systems definition in order to benefit from human competencies and capacities while respecting human limits. The main idea is to balance Human and technology involvement, taking advantage of industrial CPS advances and Human capabilities identified and implemented through Human-Machine Cooperation principles. The project HUMANISM, which is presented, aims to specify and experiment such principles.