Sinope is well-known by the historians as the birth-place of Mithridates VI Eupator, and the capital of the Kingdom of Pontus. That is why the city was a strategic point to catch during the Mithridatic Wars. This paper will study in a first point the catch of the city by Lucullus in 70 BC and the treatment of the town and inhabitants of Sinope, then the situation of Sinope under the domination of Pompey, in the new Roman province of Bithynia et Pontus. In a third point, this paper will study the deduction of the Cesarian colony in Sinope, the Colonia Iulia Felix Sinope, and finally the situation of the town and inhabitants under the High Empire.