Bone Phenotyping Approaches in Human, Mice and Zebrafish – Expert Overview of the EU Cost Action GEMSTONE (“GEnomics of MusculoSkeletal traits TranslatiOnal NEtwork”) - Laboratoire de Biologie de l'Exercice pour la Performance et la Santé Accéder directement au contenu
Article Dans Une Revue Frontiers in Endocrinology Année : 2021

Bone Phenotyping Approaches in Human, Mice and Zebrafish – Expert Overview of the EU Cost Action GEMSTONE (“GEnomics of MusculoSkeletal traits TranslatiOnal NEtwork”)

1 Medical University of Graz = Medizinische Universität Graz
2 Imperial College London
3 UiT - The Arctic University of Norway [Tromsø, Norway]
4 Oslo University Hospital [Oslo]
5 University Medical Center
6 ULISBOA - Universidade de Lisboa = University of Lisbon = Université de Lisbonne
7 LYOS - Physiopathologie, diagnostic et traitements des maladies osseuses / Pathophysiology, Diagnosis & Treatments of Bone Diseases
8 HCMR - Hellenic Centre for Marine Research
9 Aristotle University of Thessaloniki
10 Agricultural University of Athens
11 University of Birmingham [Birmingham]
12 JKU - University of Linz - Johannes Kepler Universität Linz
13 University of Bristol [Bristol]
14 Tampere University Hospital
15 UGENT - Universiteit Gent = Ghent University
16 IMEC - IMEC
17 Aarhus University Hospital
18 RMIT University - Royal Melbourne Institute of Technology University
19 STAPS - UEVE - Département Sciences et Techniques des Activités Physiques et Sportives (Evry)
20 LBEPS - Laboratoire de Biologie de l'Exercice pour la Performance et la Santé
21 University of Ioannina
22 Lund University
23 Erasmus MC - Erasmus University Medical Center [Rotterdam]
24 Brown University
25 Sahlgrenska Academy at University of Gothenburg [Göteborg]
26 Sahlgrenska University Hospital [Gothenburg]
27 Istanbul University Cerrahpasa
28 UNIVERSITY OF SARAJEVO - UNIVERZITET U SARAJEVU
29 TU/e - Eindhoven University of Technology [Eindhoven]
30 CHCR - Clinical Hospital Center Rijeka [Rijeka, Croatia]
Fiona Mcguigan
  • Fonction : Auteur

Résumé

A synoptic overview of scientific methods applied in bone and associated research fields across species has yet to be published. Experts from the EU Cost Action GEMSTONE (“GEnomics of MusculoSkeletal Traits translational Network”) Working Group 2 present an overview of the routine techniques as well as clinical and research approaches employed to characterize bone phenotypes in humans and selected animal models (mice and zebrafish) of health and disease. The goal is consolidation of knowledge and a map for future research. This expert paper provides a comprehensive overview of state-of-the-art technologies to investigate bone properties in humans and animals – including their strengths and weaknesses. New research methodologies are outlined and future strategies are discussed to combine phenotypic with rapidly developing –omics data in order to advance musculoskeletal research and move towards “personalised medicine”.
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hal-04518575 , version 1 (05-06-2024)

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Ines Foessl, J. Bassett, Åshild Bjørnerem, Björn Busse, Ângelo Calado, et al.. Bone Phenotyping Approaches in Human, Mice and Zebrafish – Expert Overview of the EU Cost Action GEMSTONE (“GEnomics of MusculoSkeletal traits TranslatiOnal NEtwork”). Frontiers in Endocrinology, 2021, 12, pp.720728. ⟨10.3389/fendo.2021.720728⟩. ⟨hal-04518575⟩
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