Modeling the mechanical behavior of bone is very complex due to substantial variability of the mechanical response of bone. The objective of this study is to investigate the link between morphology of the human parietal bone and its mechanical behavior in compression with two different strain rates. Five formalin-preserved human skulls were used, and 10 specimens were taken from the parietal bone of each subject. The internal geometry of the osseous material was studied with a micro-tomography device. For mechanical testing, quasi-static (0.02 s –1 ) tests on a conventional compression machine and dynamic tests (1500 s –1 ) on a split Hopkinson pressure bar (SHPB) were conducted on 9 mm diameter samples. The results were used to examine relationships between the morphological parameters to find morphological correlations. Linkages between mechanical behavior and morphology of the human parietal bone were also analyzed to develop a behavior model based on micro-structure parameters as determined by micro-scanning.